![]() ![]() note possible depression myeloid elements in blood and resistance exhibited by certain gram negative bacteria accumulation of the drug may occur in patients with impaired renal or hepatic function ![]() ? aspirin is a good screening drug for G6P deficiency use w/ caution in patients with G6P defficiency (increased risk of hemolysis) dosage: apply qd to bid to burn area (dressings not required over burn area) note: resistance to silvadene is mediated by plasmids which may also confer resistance to other antibiotics nearly all enterobacter and pseudomonas will develop resistance thus, it is relatively ineffective in controlling bacterial proliferation in the eschar once high bacterial densities have occurred silver sulfadiazine is poorly soluble and has only limited ability to penetrate into the burn wound silver sulfadiazine is painless on application (and is often soothing) and causes no acid base abnormalities topical bactercidal agent effective against many gran negative and positive bacteria as well as yeast, however, is absorbed poorly through the eschar site, and is ineffective against enterobacter and pseudomonas for prevention and treatment of wound sepsis in patients with second and third degree burns Store at room temperature away from moisture and heat.- silvadene burn cream is a 1% suspension of silver sulfadiazine in a water soluble base Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Your symptoms may improve before the infection is completely cleared. Use this medicine for the full prescribed length of time. Your kidney function may also need to be tested. While using Silvadene, you may need frequent blood tests. Treated skin areas can be left uncovered, or you may use a gauze bandage if directed by your doctor. Burn wounds must be kept covered with this medicine at all times. Silver sulfadiazine cream is usually applied 1 or 2 times daily. Reapply the cream after bathing or water therapy. If needed, apply more cream to replace any medicine that has come off on bandages, clothing, or bed linens. This medicine should be applied in a layer about one 16th (1/16) of an inch thick, or 1.6 millimeters. Apply enough silver sulfadiazine to cover the affected area evenly. Take care to keep the treatment area as clean as possible to prevent further infection.Ĭlean the area to be treated as directed by your doctor. The person applying silver sulfadiazine to burn wounds should wear sterile disposable gloves. Wash your hands before and after applying silver sulfadiazine cream. Do not use Silvadene in larger or smaller amounts or for longer than recommended. You may report side effects to FDA at 1-80.įollow all directions on your prescription label. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Liver problems- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes) or Kidney problems-red or pink urine, little or no urinating, swelling, rapid weight gain Pale or yellowed skin, dark colored urine, fever, confusion or weakness ![]() Sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing Įasy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin Silvadene may cause serious side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat.Īlthough the risk of serious side effects is low when silver sulfadiazine is applied to the skin, side effects can occur if the medicine is absorbed into your bloodstream. ![]()
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